Claudin 6 (Phospho-Tyr219) Antibody

Catalog Number:

11793

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P56747;
NCBI Gene#: 9074;
NCBI Protein#: NP_067018.2.

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 219 (T-K-N-Y(p)-V) derived from Human Claudin 6.

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous levels of Claudin 6 only when phosphorylated at tyrosine 219.

Applications:

WB

Background:

Claudin 6 Plays a major role in tight junction-specific obliteration of the intercellular space. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO- 3.

Keen T.J., Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Troy T., Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
Clark H.F., Genome Res. 13:2265-2270(2003).

References:

appl_detail:

Western blotting: 1:500~1:1000

Datasheet PDF