HP1α (Phospho-Ser92) Antibody

Catalog Number:

11777

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P45973;
NCBI Gene#: 23468;
NCBI Protein#: NP_001120793.1.

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of Serine 92(R-S-S(p)-N-F) derived from Human HP1α .

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous levels of HP1α only when phosphorylated at serine 92.

Applications:

IHC

Background:

Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing.

Saunders W.S., J. Cell Sci. 104:573-582(1993).
Ye Q., J. Biol. Chem. 271:14653-14656(1996).
Ye Q., J. Biol. Chem. 272:14983-14989(1997).

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF