Product Datasheet  
HP1α (Phospho-Ser92) Antibody  
Catalog Number: 11777  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P45973;
    NCBI Gene#: 23468;
    NCBI Protein#: NP_001120793.1.
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of Serine 92(R-S-S(p)-N-F) derived from Human HP1α .
  • reactivity：  
  • Hu
  • appl_detail：  

  • Immunohistochemistry: 1:50~1:100

  • other_names：  
  • HP1A; HP1 alpha; antigen p25;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous levels of HP1α only when phosphorylated at serine 92.
  • Applications：  
  • IHC
  • Background：  

  • Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing.

    Saunders W.S., J. Cell Sci. 104:573-582(1993).
    Ye Q., J. Biol. Chem. 271:14653-14656(1996).
    Ye Q., J. Biol. Chem. 272:14983-14989(1997).




 
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