FRS2 (Phospho-Tyr436) Antibody

Catalog Number:

11769

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q8WU20;
NCBI Gene#: 10818;
NCBI Protein#: NP_001036020.1.

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 436(L-N-Y(p)-I-Q) derived from Human FRS2 .

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous levels of FRS2 only when phosphorylated at tyrosine 436.

Applications:

WB IHC

Background:

FRS2 is an adaptor protein involved in fibroblast growth factor receptor (FGFR) signaling. Plays an important role in linking FGFR and nerve growth factor receptors with Ras/MAPK signaling pathways.

Xu H., J. Biol. Chem. 273:17987-17990(1998).
Meakin S.O., J. Biol. Chem. 274:9861-9870(1999).
Dhalluin C., Mol. Cell 6:921-929(2000).

References:

appl_detail:

Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100

Datasheet PDF