Product Datasheet  
FRS2 (Phospho-Tyr436) Antibody  
Catalog Number: 11769  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q8WU20;
    NCBI Gene#: 10818;
    NCBI Protein#: NP_001036020.1.
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of tyrosine 436(L-N-Y(p)-I-Q) derived from Human FRS2 .
  • reactivity：  
  • Hu
  • appl_detail：  

  • Western blotting: 1:500~1:1000
    Immunohistochemistry: 1:50~1:100

  • other_names：  
  • SNT-1; SNT2; FGFR signalling adaptor;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous levels of FRS2 only when phosphorylated at tyrosine 436.
  • Applications：  
  • WB IHC
  • Background：  

  • FRS2 is an adaptor protein involved in fibroblast growth factor receptor (FGFR) signaling. Plays an important role in linking FGFR and nerve growth factor receptors with Ras/MAPK signaling pathways.

    Xu H., J. Biol. Chem. 273:17987-17990(1998).
    Meakin S.O., J. Biol. Chem. 274:9861-9870(1999).
    Dhalluin C., Mol. Cell 6:921-929(2000).




 
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