VEGFR1 (Phospho-Tyr1048) Antibody

Catalog Number:

11759

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P17948;
NCBI Gene#: 2321;
NCBI Protein#: NP_002010.2.

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 1048 (D-I-Y(p)-K-N) derived from Human VEGFR1.

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous levels of VEGFR1 only when phosphorylated at tyrosine 1048.

Applications:

IHC

Background:

Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis.

Shibuya M., Oncogene 5:519-524(1990).
Kendall R.L., Proc. Natl. Acad. Sci. U.S.A. 90:10705-10709(1993).
The MGC Project Team; Genome Res. 14:2121-2127(2004).

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF