IKK-γ (Phospho-Ser376) Antibody

Catalog Number:

11732

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9Y6K9;
NCBI Gene#: 8517;
NCBI Protein#: NP_001093327.1.

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of Serine 376(Y-L-S(p)-S-P) derived from Human IKK-γ.

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous levels of IKK-γ only when phosphorylated at serine 376.

Applications:

IHC

Background:

Familial incontinentia pigmenti (IP) is a genodermatosis that segregates as an X-linked dominant disorder and is usually lethal prenatally in males. In affected females it causes highly variable abnormalities of the skin, hair, nails, teeth, eyes, and central nervous system. The prominent skin signs occur in 4 classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation, and dermal scarring. Cells expressing the mutated X chromosome are eliminated selectively around the time of birth, so females with IP exhibit extremely skewed X-inactivation.

Li Y., Proc. Natl. Acad. Sci. U.S.A. 96:1042-1047(1999).
Jin D.-Y., J. Biomed. Sci. 6:115-120(1999).
Rothwarf D.M., Nature 395:297-300(1998).

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF