Product Datasheet  
IKK-γ (Phospho-Ser376) Antibody  
Catalog Number: 11732  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q9Y6K9;
    NCBI Gene#: 8517;
    NCBI Protein#: NP_001093327.1.
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of Serine 376(Y-L-S(p)-S-P) derived from Human IKK-γ.
  • reactivity：  
  • Hu
  • appl_detail：  

  • Immunohistochemistry: 1:50~1:100

  • other_names：  
  • FIP3; IKBKG; IKKAP1; IKKG; NF-kappaB
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous levels of IKK-γ only when phosphorylated at serine 376.
  • Applications：  
  • IHC
  • Background：  

  • Familial incontinentia pigmenti (IP) is a genodermatosis that segregates as an X-linked dominant disorder and is usually lethal prenatally in males. In affected females it causes highly variable abnormalities of the skin, hair, nails, teeth, eyes, and central nervous system. The prominent skin signs occur in 4 classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation, and dermal scarring. Cells expressing the mutated X chromosome are eliminated selectively around the time of birth, so females with IP exhibit extremely skewed X-inactivation.

    Li Y., Proc. Natl. Acad. Sci. U.S.A. 96:1042-1047(1999).
    Jin D.-Y., J. Biomed. Sci. 6:115-120(1999).
    Rothwarf D.M., Nature 395:297-300(1998).




 
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