ITGB4 (Phospho-Tyr1510) Antibody

Catalog Number:

11698

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P16144;
NCBI Gene#: 3691;
NCBI Protein#: NP_000204.3.

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of tyrosine1510(R-D-Y(p)-S-T) derived from Human ITGB4 .

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous levels of ITGB4 only when phosphorylated at tyrosine 1510.

Applications:

ELISA

Background:

Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.

Suzuki S., EMBO J. 9:757-763(1990).
Hogervorst F., EMBO J. 9:765-770(1990).
Tamura R.N., J. Cell Biol. 111:1593-1604(1990).

References:

appl_detail:

Datasheet PDF