Product Datasheet  
ITGB4 (Phospho-Tyr1510) Antibody  
Catalog Number: 11698  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P16144;
    NCBI Gene#: 3691;
    NCBI Protein#: NP_000204.3.
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of tyrosine1510(R-D-Y(p)-S-T) derived from Human ITGB4 .
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • GP150; ITB4; CD104 antigen;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous levels of ITGB4 only when phosphorylated at tyrosine 1510.
  • Applications：  
  • ELISA
  • Background：  

  • Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.

    Suzuki S., EMBO J. 9:757-763(1990).
    Hogervorst F., EMBO J. 9:765-770(1990).
    Tamura R.N., J. Cell Biol. 111:1593-1604(1990).




 
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