Histamine H1 Receptor (Phospho-Ser398) Antibody

Catalog Number:

11695

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P35367;
NCBI Gene#: 3269;
NCBI Protein#: NP_000852.1.

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of Serine 398(S-H-S(p)-R-Q) derived from Human Histamine H1 Receptor .

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous levels of Histamine H1 Receptor only when phosphorylated at serine 398.

Applications:

IF

Background:

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

de Backer M.D., Biochem. Biophys. Res. Commun. 197:1601-1608(1993).
Fukui K., Biochem. Biophys. Res. Commun. 201:894-901(1994).
Sjoeblom T., Science 314:268-274(2006)

References:

appl_detail:

Immunofluorescence: 1:100~1:200

Datasheet PDF