Product Datasheet  
Histamine H1 Receptor (Phospho-Ser398) Antibody  
Catalog Number: 11695  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P35367;
    NCBI Gene#: 3269;
    NCBI Protein#: NP_000852.1.
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of Serine 398(S-H-S(p)-R-Q) derived from Human Histamine H1 Receptor .
  • reactivity：  
  • Hu
  • appl_detail：  

  • Immunofluorescence: 1:100~1:200

  • other_names：  
  • H1-R; HRH1; histamine H1 receptor;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous levels of Histamine H1 Receptor only when phosphorylated at serine 398.
  • Applications：  
  • IF
  • Background：  

  • In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

    de Backer M.D., Biochem. Biophys. Res. Commun. 197:1601-1608(1993).
    Fukui K., Biochem. Biophys. Res. Commun. 201:894-901(1994).
    Sjoeblom T., Science 314:268-274(2006)




 
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