SIK3 Antibody

Catalog Number:

25394

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9Y2K2
Gene ID:23387

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against an 18 amino acid peptide near the carboxy terminus of human SIK3.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least three isoforms of SIK3 are known to exist; this antibody will detect two isoforms. SIK3 antibody is predicted to not cross-react with SIK1 and SIK2.

Applications:

ELISA WB

Background:

Salt-inducible kinase family (SIKs) proteins are thought to have a role in steroidogenesis, adipogenesis or regulation of tumor malignancy. Three members (SIK1, SIK2 and SIK3) in the SIK family have been identified thus far. Their kinase domain sequences are closely homologous to those of AMP-activated protein kinase (AMPK). SIK3 can be phosphorylated by a tumor-suppressor kinase LKB1. It is highly and preferentially expressed in ovarian tumors but not in adenomyosis and leiomyoma and may be a potential diagnostic marker for ovarian cancers.

References:

appl_detail:

Datasheet PDF