ZGPAT Antibody

Catalog Number:

25393

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q8N5A5
Gene ID:84619

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 15 amino acid peptide near the carboxy terminus of human ZGPAT.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

Multiple isoforms of ZGPAT are known to exist.

Applications:

ELISA WB

Background:

The Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT), is a transcriptional repressor that regulates several cellular pathways including EGFR pathways that are involved in cell proliferation, migration and survival. ZGPAT recruits the Mi-2/NuRD complex and represses the expression of EGFR. ZGPAT is down-regulated in breast carcinomas and its expression is negatively correlated with that of EGFR, suggesting that it may be a potential target for breast cancer therapy. Multiple isoforms of ZGPAT are known to exist, including sZIP, which binds to the Mi-2/NuRD complex but lacks the DNA binding component of full-length ZGPAT, thereby antagonizing transcription repression and growth inhibition by ZGPAT.

References:

appl_detail:

Datasheet PDF