Product Datasheet  
ZGPAT Antibody  
Catalog Number: 25393  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Chicken
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q8N5A5
    Gene ID:84619
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 15 amino acid peptide near the carboxy terminus of human ZGPAT.
  • reactivity：  
  • Hu
  • appl_detail：  
  • other_names：  
  • Zinc finger CCCH-type with G patch domain-containing protein, ZIP, ZC3H9, ZC3HDC9, GPATC6, GPATCH6
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • Multiple isoforms of ZGPAT are known to exist.
  • Applications：  
  • ELISA WB
  • Background：  
  • The Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT), is a transcriptional repressor that regulates several cellular pathways including EGFR pathways that are involved in cell proliferation, migration and survival. ZGPAT recruits the Mi-2/NuRD complex and represses the expression of EGFR. ZGPAT is down-regulated in breast carcinomas and its expression is negatively correlated with that of EGFR, suggesting that it may be a potential target for breast cancer therapy. Multiple isoforms of ZGPAT are known to exist, including sZIP, which binds to the Mi-2/NuRD complex but lacks the DNA binding component of full-length ZGPAT, thereby antagonizing transcription repression and growth inhibition by ZGPAT.



 
© Signalway Biotechnology All Rights Reserved.