β-Catenin Antibody

Catalog Number:

47993

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q02248

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

peptide

Purification:

Immunogen affinity purified

Specificity/Sensitivity:

Applications:

WB, ICC, IHC

Background:

β-Catenin is a multifunctional adaptor protein involved in cadherin-mediated cellCcell adhesion and in responding to the activation of several signal transduction pathways. CK1 phosphorylates β-catenin on Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37 and Thr41.). Mutations in β-Catenin have been implicated in its accumulation and various forms of carcinomas.

References:

appl_detail:

WB 1:1,000

ICC: 1:200

Datasheet PDF