Fbx32 Antibody

Catalog Number:

49987

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q969P5

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

Recombinant protein corresponding to human Fbx32 1-200aa.

Purification:

ProA affinity purified

Specificity/Sensitivity:

Applications:

WB,ICC

Background:

Muscle atrophy F-box (MAFbx) is an E3 ubiquitin ligase that initiates ATP-dependent ubiquitin-mediated proteolysis and promotes muscle atrophy. MAFbx transcript is abundant in cardiac and skeletal muscle undergoing atrophy. MAFbx -/- mice are resistant to muscle atrophy. MAFbx is thought to recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation during skeletal muscle atrophy. It interacts with MyoD by ubiquitination via a sequence found in transcriptional coactivators and therefore may play an important role in the course of muscle differentiation by determining the abundance of MyoD. MAFbx is specifically expressed in cardiac and skeletal muscle.

References:

appl_detail:

WB: 1:500-1:1,000

ICC: 1:50-1:200

Datasheet PDF