Product Datasheet  
Fbx32 Antibody  
Catalog Number: 49987  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q969P5
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein corresponding to human Fbx32 1-200aa.
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:500-1:1,000

    ICC: 1:50-1:200

  • other_names：  
  • 4833442G10Rik antibody
    AI430017 antibody
    Atrogin 1 antibody
    Atrogin-1 antibody
    ATROGIN1 antibody
    Atrophy gene 1 antibody
    F box only protein 32 antibody
    F-box only protein 32 antibody
    F-box pro
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB,ICC
  • Background：  
  • Muscle atrophy F-box (MAFbx) is an E3 ubiquitin ligase that initiates ATP-dependent ubiquitin-mediated proteolysis and promotes muscle atrophy. MAFbx transcript is abundant in cardiac and skeletal muscle undergoing atrophy. MAFbx -/- mice are resistant to muscle atrophy. MAFbx is thought to recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation during skeletal muscle atrophy. It interacts with MyoD by ubiquitination via a sequence found in transcriptional coactivators and therefore may play an important role in the course of muscle differentiation by determining the abundance of MyoD. MAFbx is specifically expressed in cardiac and skeletal muscle.



 
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