PICK1 Antibody

Catalog Number:

49929

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q9NRD5

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

Recombinant protein within N-terminal human PICK1.

Purification:

ProA affinity purified

Specificity/Sensitivity:

Applications:

WB,IP,FC

Background:

Protein interacting with C kinase 1 (PICK1) is a PDZ-domain containing protein that is located in the perinuclear region and is phosphorylated in response to PKCα activation. PKCα, which is essential for the regulation of proliferation and differentiation in numerous cell types, contains within its catalytic region a PDZ-binding domain that is absent from other PKC isoforms. Mutation of the PICK1 PDZ domain inhibits the binding of PICK1 to PKCα. PICK1 also interacts with the carboxy terminus of a-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor, a neurotransmitter receptor located at excitatory synapses, suggesting that PICK1 plays a role in the modulation of synaptic transmission by targeting and anchoring AMPA to specific synapses.

References:

appl_detail:

WB: 1:2,000-1:5,000


IP: 1:10-1:50
FC: 1:50-1:100

Datasheet PDF