Product Datasheet  
PICK1 Antibody  
Catalog Number: 49929  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q9NRD5
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein within N-terminal human PICK1.
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:2,000-1:5,000


    IP: 1:10-1:50
    FC: 1:50-1:100
  • other_names：  
  • dJ1039K5 antibody
    MGC15204 antibody
    OTTHUMP00000028509 antibody
    PICK 1 antibody
    Pick1 antibody
    PICK1_HUMAN antibody
    PRKCA binding protein antibody
    PRKCA-binding protein antibody
    PRKCABP antibody<
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB,IP,FC
  • Background：  
  • Protein interacting with C kinase 1 (PICK1) is a PDZ-domain containing protein that is located in the perinuclear region and is phosphorylated in response to PKCα activation. PKCα, which is essential for the regulation of proliferation and differentiation in numerous cell types, contains within its catalytic region a PDZ-binding domain that is absent from other PKC isoforms. Mutation of the PICK1 PDZ domain inhibits the binding of PICK1 to PKCα. PICK1 also interacts with the carboxy terminus of a-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor, a neurotransmitter receptor located at excitatory synapses, suggesting that PICK1 plays a role in the modulation of synaptic transmission by targeting and anchoring AMPA to specific synapses.



 
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