SAE1 Antibody

Catalog Number:

49894

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q9UBE0

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

Recombinant protein within human SAE1 aa 150-300.

Purification:

ProA affinity purified

Specificity/Sensitivity:

Applications:

WB,FC

Background:

Proteolytic degradation by the ubiquitin (Ub) system is essential for normal cell cycle progression, cellular differentiation and stress responses. Proteins conjugated to Ub are marked for progressive degradation by the 26S Proteasome. AOS-1, also designated SUMO-1-activating enzyme or ubiquitin-like 1-activating enzyme E1A, belongs to the ubiquitin-activating E1 family of proteins and plays an important role in the first step of the UBL1 conjugation pathway. AOS-1, which is a dimeric enzyme, functions as a UBLI E1 ligase, mediating the ATP-dependent activation of UBL1. AOS-1 can bind with UBLE1A and UBLE1B to form a heterodimer which can bind UBL1.

References:

appl_detail:

WB: 1:500-1:2,000



FC: 1:50-1:100

Datasheet PDF