Mib1 Antibody

Catalog Number:

49913

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q86YT6

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

Recombinant protein within N-terminal human Mib1.

Purification:

ProA affinity purified

Specificity/Sensitivity:

Applications:

WB,ICC,IHC

Background:

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.

References:

appl_detail:

IHC: 1:50-1:200
ICC: 1:50-1:200

Datasheet PDF