Product Datasheet  
Mib1 Antibody  
Catalog Number: 49913  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q86YT6
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein within N-terminal human Mib1.
  • reactivity：  
  • Hu, Ms
  • appl_detail：  

  • IHC: 1:50-1:200
    ICC: 1:50-1:200

  • other_names：  
  • DAPK-interacting protein 1 antibody
    Dip 1 antibody
    DIP-1 antibody
    Dip1 antibody
    E3 ubiquitin protein ligase MIB 1 antibody
    E3 ubiquitin protein ligase MIB1 antibody
    E3 ubiquitin-protein ligase mib1 antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB,ICC,IHC
  • Background：  
  • E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.



 
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