H Cadherin Antibody

Catalog Number:

49857

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P55290

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

Recombinant protein within human H Cadherin aa 1-200.

Purification:

ProA affinity purified

Specificity/Sensitivity:

Applications:

IHC,WB

Background:

Cadherins comprise a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogen-esis. Cadherins each contain a large extracellular domains characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as β-catenin, to regulate cadherin function. T-cadherin (for truncated-cadherin), also designated heart-cadherin or cadherin-13) expression levels have been shown to be reduced in human breast cancers and carcinoma cell lines. Evidence suggests that decreased levels of T-cadherin indicate a progression in breast malignancies.

References:

appl_detail:

IHC: 1:50-1:200

Datasheet PDF