Sequestosome-1 Antibody

Catalog Number:

48357

Amount:

100μg

Price:

$529

Swiss-Prot No:

Swiss-Prot#:Q13501

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

Synthetic peptide (KLH-coupled) within human SQSTM1 40-100 aa.

Purification:

Peptide affinity purified.

Specificity/Sensitivity:

Applications:

WB, ICC, IHC, FC

Background:

Sequestosome 1 (SQSTM1, p62) is a ubiquitin binding protein involved in cell signaling, oxidative stress and autophagy. It was first identified as a protein that binds to the SH2 domain of p56Lck and independently found to interact with PKCζ. SQSTM1 was subsequently found to interact with ubiquitin, providing a scaffold for several signaling proteins and triggering degradation of proteins through the proteasome or lysosome. Interaction between SQSTM1 and TRAF6 leads to the K63-linked polyubiquitination of TRAF6 and subsequent activation of the NF-κB pathway. It may play a role in titin/TTN downstream signaling in muscle cells and regulate signaling cascades through ubiquitination. P62 may be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.

References:

appl_detail:

WB: 1:500-1:1,000
IHC: 1:200
ICC: 1:200

FC: 1 μg per 1 x 106 cells

Datasheet PDF