Product Datasheet  
Sequestosome-1 Antibody  
Catalog Number: 48357  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q13501
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthetic peptide (KLH-coupled) within human SQSTM1 40-100 aa.
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:500-1:1,000
    IHC: 1:200
    ICC: 1:200

    FC: 1 μg per 1 x 106 cells
  • other_names：  
  • A170 antibody
    DMRV antibody
    EBI 3 associated protein of 60 kDa antibody
    EBI 3 associated protein p60 antibody
    EBI3 associated protein of 60 kDa antibody
    EBI3 associated protein p60 antibody
    EBI3-associated protein of 60 kDa antibody
    EBIAP antibody
    FTDALS3 antibody
    MGC127197 antibody
    ORCA antibody
    OSF-6 antibody
    Osi antibody
    OSIL antibody
    Oxidative stress induced like antibody
    p60 antibody
    p62 antibody
    p62B antibody
    Paget disease of bone 3 antibody
    PDB 3 antibody
    PDB3 antibody
    Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa antibody
    Phosphotyrosine independent ligand for the Lck SH2 domain p62 antibody
    Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa antibody
    PKC-zeta-interacting protein antibody
    Protein kinase C-zeta-interacting protein antibody
    Sequestosome 1 antibody
    Sequestosome-1 antibody
    SQSTM 1 antibody
    SQSTM_HUMAN antibody
    Sqstm1 antibody
    STAP antibody
    STONE14 antibody
    Ubiquitin binding protein p62 antibody
    Ubiquitin-binding protein p62 antibody
    ZIP 3 antibody
    ZIP antibody
    ZIP3 antibody
  • Purification：  
  • Peptide affinity purified.
  • Specificity：  
  • Applications：  
  • WB, ICC, IHC, FC
  • Background：  
  • Sequestosome 1 (SQSTM1, p62) is a ubiquitin binding protein involved in cell signaling, oxidative stress and autophagy. It was first identified as a protein that binds to the SH2 domain of p56Lck and independently found to interact with PKCζ. SQSTM1 was subsequently found to interact with ubiquitin, providing a scaffold for several signaling proteins and triggering degradation of proteins through the proteasome or lysosome. Interaction between SQSTM1 and TRAF6 leads to the K63-linked polyubiquitination of TRAF6 and subsequent activation of the NF-κB pathway. It may play a role in titin/TTN downstream signaling in muscle cells and regulate signaling cascades through ubiquitination. P62 may be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.



 
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