IFN alpha R1 Antibody

Catalog Number:

48307

Amount:

100μg

Price:

$529

Swiss-Prot No:

Swiss-Prot#:P33896

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

The extracellular domain of IFN-αR1 of mouse origin.

Purification:

ProA affinity purified

Specificity/Sensitivity:

Applications:

WB, IP, FCM

Background:

The type I interferons (IFNs), ? and , are a group of structurally and functionally related proteins that are induced by either viruses or double stranded RNA and defined by their ability to confer an antiviral state in cells. The ? and IFNs appear to compete with one another for binding to a common cell surface receptor, while immune IFN (IFN?) binds to a distinct receptor. The latter protein, IFN-?R, is only weakly responsive to type I interferons in contrast to IFN-?/R, which binds to and responds effectively to IFN- and to several of the IFN-? subtypes. Moreover, IFN-?/R is physically associated with the cytoplasmic tyrosine kinase JAK1 and thus, in addition to ligand binding, appears to be functionally involved in signal transduction. IFN-?R1 is a receptor for IFN-?/ and is present as the full chain (IFN-?R1a) and as a splice-variant (IFN-?R1). The IFN-? receptor complex consists of an alpha subunit (IFN-?R?) and a beta subunit that is 332 amino acids in length (mouse) and 337 amino acids in length (human).

References:

appl_detail:

WB: 1:100-1:1,000


IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
FC: 1 μg per 1 x 106 cells

Datasheet PDF