HLA E Antibody

Catalog Number:

48304

Amount:

100μg

Price:

$529

Swiss-Prot No:

Swiss-Prot#:P13747

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

Recombinant HLA-E of human origin

Purification:

ProA affinity purified

Specificity/Sensitivity:

Applications:

WB, IP, FCM

Background:

Major histocompatibility complex (MHC) molecules, which include human leukocyte antigens (HLAs), form an integral part of the immune response system. They are cell surface receptors that bind foreign peptides and present them to cytotoxic T lymphocytes (CTLs). MHC class I molecules consist of two polypeptide chains, an α or heavy chain and a non-covalently associated pro- tein, β-2-Microglobulin. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. HLA-A is a MHC class I heavy chain molecule that plays a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and HLA-C are proteins encod- ed by closely related genes that also exist in the MHC class I. HLA-E belongs to the HLA class I heavy chain paralog. HLA-E is a heterodimer consisting of a heavy chain and a light chain; the heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules.

References:

appl_detail:

WB: 1:100-1:1,000


IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) FCM: 1 μg per 1 x 106 cells
FC: 1 μg per 1 x 106 cells

Datasheet PDF