PCNA Mouse Monoclonal Antibody

Catalog Number:

37978

Amount:

100μg

Price:

$529

Swiss-Prot No:

Swiss-Prot:P12004
Gene ID:5111

Form of Antibody:

Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Purification:

Affinity purification using immunogen.

Specificity/Sensitivity:

Antibody can detect endogenous?PCNA protein.

Applications:

WB,IHC,IF

Background:

PCNA is a marker for cells in early G1 phase and S phase of the cell cycle. It is found in the nucleus and is a cofactor of DNA polymerase delta. PCNA acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6 dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for PCNA. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.

References:

appl_detail:

WB dilution: 1:5000
IHC dilution: 1:200

IF dilution:1:200

Datasheet PDF