D-3-phosphoglycerate dehydrogenase Polyclonal Antibody

Catalog Number:

42388

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O43175

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human D-3-phosphoglycerate dehydrogenase protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total D-3-phosphoglycerate dehydrogenase polyclonal antibody.

Applications:

WB IHC

Background:

PHGDH or 3-phosphoglycerate dehydrogenase is an enzyme belonging to the D-isomer specific 2-hydroxyacid dehydrogenase family. It catalysis the reaction 3-phosphoglycerate + NAD+ = 3-phosphonooxypyruvate + NADH during L-serine biosynthesis. Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency). It is characterized by congenital microcephaly, psychomotor retardation and seizures.

References:

[1] "Nucleotide sequence and differential expression of the human 3-phosphoglycerate dehydrogenase gene."Cho H.M., Jun D.Y., Bae M.A., Ahn J.D., Kim Y.H.Gene 245:193-201(2000) [2] "Molecular characterization of 3-phosphoglycerate dehyd

appl_detail:

Western blotting: 1:500 - 1:1000
Immunohistochemistry: 1:20 - 1:200

Datasheet PDF