Kynurenine 3-monooxygenase Polyclonal Antibody

Catalog Number:

42233

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O15229

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Kynurenine 3-monooxygenase protein(1-486aa)

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Kynurenine 3-monooxygenase polyclonal antibody.

Applications:

IHC

Background:

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.

References:

[1]"Endogenous kynurenines as targets for drug discovery and development."Stone T.W., Darlington L.G.Nat. Rev. Drug Discov. 1:609-620(2002).

appl_detail:

Immunohistochemistry: 1:20 - 1:200

Datasheet PDF