NFκB p65 Mouse Monoclonal Antibody

Catalog Number:

38008

Amount:

100μg

Price:

$369

Swiss-Prot No:

Swiss-Prot#:Q04206

Form of Antibody:

Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Purification:

Affinity purification using immunogen.

Specificity/Sensitivity:

NFκB p65 Mouse monoclonal antibody detects endogenous p65 proteins.

Applications:

WB,IHC

Background:

NFkB p65 is ubiquitinated leading to its proteosomal degradation, which is required for termination of the NFkB response. Phosphorylation of NFkB p65 on S536 stimulates acetylation of K310 by CBP, enhancing transcriptional activity. NFkB p65 is also acetylated at K122, enhancing DNA binding and impairing the interaction with NFKBIA. The protein is deacetylated by HDAC3. Invasion of a host by a pathogen is frequently associated with the activation of NF-kB, which coordinates various aspects of immune function required for resistance to infection.

References:

appl_detail:

Western blotting: 1:1000~1:3000
Immunohistochemistry: 1:200

Datasheet PDF