Product Datasheet  
NFκB p65 Mouse Monoclonal Antibody  
Catalog Number: 38008  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q04206
  • Form of Antibody：  
  • Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:1000~1:3000
    Immunohistochemistry: 1:200
  • other_names：  
  • p65; NFKB3
  • Purification：  
  • Affinity purification using immunogen.
  • Specificity：  
  • NFκB p65 Mouse monoclonal antibody detects endogenous p65 proteins.
  • Applications：  
  • WB,IHC
  • Background：  
  • NFkB p65 is ubiquitinated leading to its proteosomal degradation, which is required for termination of the NFkB response. Phosphorylation of NFkB p65 on S536 stimulates acetylation of K310 by CBP, enhancing transcriptional activity. NFkB p65 is also acetylated at K122, enhancing DNA binding and impairing the interaction with NFKBIA. The protein is deacetylated by HDAC3. Invasion of a host by a pathogen is frequently associated with the activation of NF-kB, which coordinates various aspects of immune function required for resistance to infection.



 
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