WDR77 Monoclonal Antibody

Catalog Number:	27213
other_names:	2610312E17Rik; Androgen receptor cofactor p44; C79984; HKMT1069; MEP 50; MEP-50; MEP50; MEP50_HUMAN; Methylosome protein 50; MGC2722; Nbla10071; p44; p44/Mep50; RGD1310479; RP11 552M11.3; WD repeat containing protein 77; WD repeat domain 77;
Amount:	100μg
calculated_mw:
host_species:	Mouse
Price:	$369
Swiss-Prot No:	Uniprot: Q9BQA1 Gene ID: 79084
Form of Antibody:	Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Storage/Stability:
Immunogen:	Purified recombinant human WDR77 protein fragments expressed in E.coli.
Purification:	Affinity purified
Specificity/Sensitivity:	This antibody detects endogenous levels of WDR77 and does not cross-react with related proteins.
Applications:	WB ICC
Background:	Non-catalytic component of the 20S PRMT5-containing methyltransferase complex,which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones.This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles.Might play a role in transcription regulation.The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4),methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.
References:
appl_detail:	Western blotting: 1:1000 Immunocytochemistry: 1:100
	Datasheet PDF

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