p53 (C-terminus) Monoclonal Antibody

Catalog Number:

27172

Amount:

100μg

Price:

$369

Swiss-Prot No:

Uniprot: P04637

Gene ID: 7157

Form of Antibody:

Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Purified recombinant human p53 protein fragments expressed in E.coli.

Purification:

Affinity purified

Specificity/Sensitivity:

This antibody detects endogenous levels of p53 and does not cross-react with related proteins.

Applications:

WB

Background:

 Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

References:

appl_detail:

 Western blotting: 1:1000

Datasheet PDF