Product Datasheet  
p53 (C-terminus) Monoclonal Antibody  
Catalog Number: 27172  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Uniprot: P04637

    Gene ID: 7157

  • Form of Antibody：  
  • Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • store at -20˚C
  • Immunogen：  
  • Purified recombinant human p53 protein fragments expressed in E.coli.
  • reactivity：  
  • Hu
  • appl_detail：  

  •  Western blotting: 1:1000

  • other_names：  
  • P53; LFS1; TRP53; TP53
  • Purification：  
  • Affinity purified
  • Specificity：  
  • This antibody detects endogenous levels of p53 and does not cross-react with related proteins.
  • Applications：  
  • WB
  • Background：  

  •  Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.




 
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