Bmi1 Monoclonal Antibody

Catalog Number:	27170
other_names:	B lymphoma Mo MLV insertion region (mouse); B lymphoma Mo MLV insertion region 1 homolog;Bmi 1; BMI1; BMI1 polycomb ring finger oncogene; BMI1_HUMAN; Flvi 2/bmi 1; FLVI2/BMI1; MGC12685; Murine leukemia viral (bmi 1) oncogene homolog;Oncogene BMI 1; PCGF 4
Amount:	100μg
calculated_mw:
host_species:	Mouse
Price:	$369
Swiss-Prot No:	UniProt: P35226 Gene ID: 648
Form of Antibody:	Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine(pH 7.4,150 mM NaCl)with 0.2% sodium azide,0.1mg/mlBSA and 50% glycerol.
Storage/Stability:
Immunogen:	Purified recombinant human Bmi1 protein fragments expressed in E.coli.
Purification:	Affinity purified
Specificity/Sensitivity:	This antibody detects endogenous levels of Bmi1 and does not cross-react with related proteins.
Applications:	WB
Background:	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
References:
appl_detail:	Western blotting: 1:1000
	Datasheet PDF

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