Product Datasheet  
Bmi1 Monoclonal Antibody  
Catalog Number: 27170  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • UniProt: P35226

    Gene ID: 648

  • Form of Antibody：  
  • Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine(pH 7.4,150 mM NaCl)with 0.2% sodium azide,0.1mg/mlBSA and 50% glycerol.
  • Storage：  
  • store at -20˚C
  • Immunogen：  
  • Purified recombinant human Bmi1 protein fragments expressed in E.coli.
  • reactivity：  
  • Hu
  • appl_detail：  

  • Western blotting: 1:1000

  • other_names：  
  • B lymphoma Mo MLV insertion region (mouse); B lymphoma Mo MLV insertion region 1 homolog;Bmi 1; BMI1; BMI1 polycomb ring finger oncogene; BMI1_HUMAN; Flvi 2/bmi 1; FLVI2/BMI1; MGC12685; Murine leukemia viral (bmi 1) oncogene homolog;Oncogene BMI 1; PCGF 4
  • Purification：  
  • Affinity purified
  • Specificity：  
  • This antibody detects endogenous levels of Bmi1 and does not cross-react with related proteins.
  • Applications：  
  • WB
  • Background：  

  •  Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.




 
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