RNF7 Antibody

Catalog Number:

40323

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9UBF6
Gene Accssion:BC005966

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Full length fusion protein

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total RNF7 protein.

Applications:

WB IHC

Background:

The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B).?

References:

appl_detail:

Western blotting: 1:200-1:1000
Immunohistochemistry:1:10-1:50

Datasheet PDF