PUMA Monoclonal Antibody

Catalog Number:

26013

Amount:

100μg

Price:

$529

Swiss-Prot No:

Q9BXH1

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha.

Purification:

Immunoaffinity chromotography purified IgG

Specificity/Sensitivity:

Applications:

ELISA WB

Background:

Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAα and PUMAβ. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

References:

appl_detail:

Datasheet PDF