Product Datasheet  
PUMA Monoclonal Antibody  
Catalog Number: 26013  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Q9BXH1
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year.
  • Immunogen：  
  • Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha.
  • reactivity：  
  • Hu Rt
  • appl_detail：  
  • other_names：  
  • PUMA (10D4G7), p53 upregulated modulator of apoptosis, bbc3, Bcl-2 binding component 3
  • Purification：  
  • Immunoaffinity chromotography purified IgG
  • Specificity：  
  • Applications：  
  • ELISA WB
  • Background：  
  • Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAα and PUMAβ. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.



 
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