DMP1 antibody

Catalog Number:

38779

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q13316
NCBI Gene ID: 1758

Form of Antibody:

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage/Stability:

Immunogen:

Recombinant fusion protein containing a sequence corresponding to amino acids 254-513 of human DMP1 (NP_004398.1).

Purification:

Antibodies were purified by affinity purification using immunogen.

Specificity/Sensitivity:

The antibody detects endogenous level of total DMP1 antibody.

Applications:

WB

Background:

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.

References:

appl_detail:

Western blotting: 1:500 - 1:2000

Datasheet PDF