Product Datasheet  
DMP1 antibody  
Catalog Number: 38779  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q13316
    NCBI Gene ID: 1758
  • Form of Antibody：  
  • PBS with 0.02% sodium azide,50% glycerol,pH7.3.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant fusion protein containing a sequence corresponding to amino acids 254-513 of human DMP1 (NP_004398.1).
  • reactivity：  
  • Hu Ms
  • appl_detail：  

  • Western blotting: 1:500 - 1:2000

  • other_names：  
  • ARHP; ARHR; DMP-1;
  • Purification：  
  • Antibodies were purified by affinity purification using immunogen.
  • Specificity：  
  • The antibody detects endogenous level of total DMP1 antibody.
  • Applications：  
  • WB
  • Background：  

  • Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.




 
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