MC1R antibody

Catalog Number:

38533

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q01726
NCBI Gene ID: 4157

Form of Antibody:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

A synthesized peptide derived from human MSHR, corresponding to a region within C-terminal amino acids.

Purification:

The antiserum was purified by peptide affinity chromatography.

Specificity/Sensitivity:

MC1R Antibody detects endogenous levels of total MC1R.

Applications:

WB IHC IF

Background:

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer.

References:

appl_detail:

Western blotting: 1:500 - 1:1000
Immunohistochemistry: 1:50 - 1:200

IF dilution: 1:100 - 1:500

Datasheet PDF