Product Datasheet  
MC1R antibody  
Catalog Number: 38533  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q01726
    NCBI Gene ID: 4157
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • A synthesized peptide derived from human MSHR, corresponding to a region within C-terminal amino acids.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Western blotting: 1:500 - 1:1000
    Immunohistochemistry: 1:50 - 1:200

    IF dilution: 1:100 - 1:500

  • other_names：  
  • CMM5; MSH-R; SHEP2; MC1-R; MC1R; Melanocortin 1 receptor; Melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); Melanocortin receptor 1; Melanocyte-stimulating hormone receptor; Melanotropin receptor; MSH-R; MSHR; MSHR_HUMAN
  • Purification：  
  • The antiserum was purified by peptide affinity chromatography.
  • Specificity：  
  • MC1R Antibody detects endogenous levels of total MC1R.
  • Applications：  
  • WB IHC IF
  • Background：  

  • This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer.




 
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