SIGLEC8 Antibody

Catalog Number:

37922

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9NYZ4
NCBI Gene ID: 27181
Gene Accssion: NP_055257/Q9NYZ4

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human sialic acid binding Ig-like lectin 8

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SIGLEC8 protein.

Applications:

WB IHC

Background:

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

WB dilution: 1:500-1:2000

IHC dilution: 1:50-1:200

Datasheet PDF