SASH1 Antibody

Catalog Number:

37895

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O94885
NCBI Gene ID: 23328
Gene Accssion: NP_056093/O94885

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human SAM and SH3 domain containing 1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SASH1 protein.

Applications:

IHC

Background:

SASH1 (SAM and SH3 domain-containing protein 1), also known as PEPE1 (Proline-glutamate repeat-containing protein), is a 1247 amino acid protein that is significantly downregulated in the majority of primary breast tumor tissues, breast cancer cell lines, lung and thyroid tumors, as well as in certain colon carcinomas. It has been hypothesized that its expression is suppressed not due to mutation of the SASH1 gene, but instead via other mechanisms, such as promoter methylation.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF