CCL4 antibody

Catalog Number:

38278

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P13236
NCBI Gene ID: 6351

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

A synthetic peptide of human CCL4.

Purification:

Antibodies were purified by affinity purification using immunogen.

Specificity/Sensitivity:

The antibody detects endogenous level of total CCL4 antibody.

Applications:

WB,IHC

Background:

Chemokines are members of a superfamily of small inducible, secreted, pro-inflammatory cytokines. Members of the chemokine family exhibit 20 to 50% homology in their predicted amino acid sequences and are divided into four subfamilies. In C-C (or b) subfamily, the first two cysteines are adjacent. C-C chemokines are chemoattractants and activators for monocytes and T cells. C-C subfamily members include macrophage inflammatory protein (MIP)-1?, MIP-1¡Ò, MIP-2, MIP-3?, MIP-3¡Ò, MIP-4, HCC-1, MIP-5 (or HCC-2), RANTES, MCP-1/2/3 (and the murine homologs JE and MARC), I-309, murine C10 and TCA3. Research has shown that MIP-1¡Ò is more selective than MIP-1?, primarily attracting CD4+ T lymphocytes, with a preference for T cells of the naive phenotype. MIP-1? is a more potent lymphocyte chemoattractant than MIP-1¡Ò and exhibits a broader range of chemoattractant specificities. It has been suggested that CD8+ T lymphocytes are involved in the control of HIV infection in vivo by the release of HIV-suppressive factors (HIV-SF). MIP-1? has been identified as one of the major HIV-SFs produced by CD8+ T cells, along with MIP-1¡Ò and RANTES. Recombinant human MIP-1? acts as an inhibitor of different strains of HIV-1, HIV-2 and SIV infection in a dose-dependent manner.

References:

appl_detail:

WB 1:500 - 1:2000
IHC 1:50 - 1:200

Datasheet PDF