Product Datasheet  
CCL4 antibody  
Catalog Number: 38278  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P13236
    NCBI Gene ID: 6351
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • A synthetic peptide of human CCL4.
  • reactivity：  
  • Human
  • appl_detail：  
  • WB 1:500 - 1:2000
    IHC 1:50 - 1:200
  • other_names：  
  • ACT2; G-26; HC21; LAG1; LAG-1; MIP1B; SCYA2; SCYA4; MIP1B1; AT744.1; MIP-1-beta;
  • Purification：  
  • Antibodies were purified by affinity purification using immunogen.
  • Specificity：  
  • The antibody detects endogenous level of total CCL4 antibody.
  • Applications：  
  • WB,IHC
  • Background：  
  • Chemokines are members of a superfamily of small inducible, secreted, pro-inflammatory cytokines. Members of the chemokine family exhibit 20 to 50% homology in their predicted amino acid sequences and are divided into four subfamilies. In C-C (or b) subfamily, the first two cysteines are adjacent. C-C chemokines are chemoattractants and activators for monocytes and T cells. C-C subfamily members include macrophage inflammatory protein (MIP)-1?, MIP-1¡Ò, MIP-2, MIP-3?, MIP-3¡Ò, MIP-4, HCC-1, MIP-5 (or HCC-2), RANTES, MCP-1/2/3 (and the murine homologs JE and MARC), I-309, murine C10 and TCA3. Research has shown that MIP-1¡Ò is more selective than MIP-1?, primarily attracting CD4+ T lymphocytes, with a preference for T cells of the naive phenotype. MIP-1? is a more potent lymphocyte chemoattractant than MIP-1¡Ò and exhibits a broader range of chemoattractant specificities. It has been suggested that CD8+ T lymphocytes are involved in the control of HIV infection in vivo by the release of HIV-suppressive factors (HIV-SF). MIP-1? has been identified as one of the major HIV-SFs produced by CD8+ T cells, along with MIP-1¡Ò and RANTES. Recombinant human MIP-1? acts as an inhibitor of different strains of HIV-1, HIV-2 and SIV infection in a dose-dependent manner.



 
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