BAP1 Antibody

Catalog Number:

36226

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q92560
NCBI Gene ID: 8314
Gene Accssion: BC001596

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from internal residues of human BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total BAP1 protein.

Applications:

WB IHC

Background:

This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma

References:

appl_detail:

Western blotting: 1:500-1:2000
Immunohistochemistry: 1:150-1:300

Datasheet PDF